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First - Resveratrol

Let's take a more detailed look at some of Resveratrol's powerful effects on the body..


The Brain - Dementia and Mental Functions

In November 2008, researchers at the Weill Medical College of Cornell University reported that Resveratrol significantly reduced plaque formation in the brain, a component of Alzheimers. They feel that oral doses of Resveratrol may reduce plaque associated with aging changes in the brain. (15)

Heart Disease

Resveratrol has been found to improve cardiovascular performance, prevent the absorption of copper (copper deficiency is a potential cause of heart failure), help maintain the heart's oxygen supply, prevent the buildup of plaque in the arteries and stop the constriction of blood vessels.(5)

Cholesterol

Resveratrol has also been found to neutralize "bad" LDL cholesterol while increasing "good" HDL cholesterols, which would reduce plaque build up in arteries which leads to heart attacks. (4)

Cancer

A 2008 study by researchers at the University of Nebraska suggest that Resveratrol may have some preventative benefits against breast cancer by disrupting the initial step that occurs when estrogen begins the process leading to cancer.

Researchers found that Resveratrol inhibits the growth of many types of cancer cells, including Leukemia, skin and prostate cancers, and reduces the incidence of tumors. Resveratrol has the potential to act as an alternative to synthetic hormone replacement therapy, which is known to increase the risk of breast cancer. (6, 7)

Cardiovascular System

Some studies suggest that the antioxidant properties of Resveratrol decreases the "stickiness" of platelets that form blood clots. (12)

Poor Diet

Resveratrol was found to counteract the life threatening effects of a high-fat diet by confronting and fighting 144 out of 153 gene pathways that had been altered by a high-fat diet. (2)

Diabetes

Scientists at the Peninsula Medical School in England discovered that Resveratrol protects blood vessels from cell damage which typically result from high glucose levels associated with Diabetes. It is the hope of many researchers that Resveratrol has the potential to greatly improve the treatment of Diabetes.

Weight Loss

When we diet or restrict the amount of calories we consume a natural reaction in our body is to activate Gene 31, our survival gene, which breaks down stored fat and increases energy levels. Numerous studies have shown that Resveratrol does the exact same thing.(18) Including Resveratrol as a supplement just may assist weightloss efforts, but without the diet. Weight loss and calorie restriction have also been proven effective against anti-aging, meaning if we take Resveratrol we may look healthier and feel younger.

Lowered Blood Sugar

A new study suggests that the Resveratrol can affect the enzymes involved in regulating glucose (blood sugar), and therefore could be an important component to maintaining healthy blood sugar levels. (11)

Increase Quality and Length of Life

Multiple studies have found that Resveratrol can extend the life span of certain cells in our bodies by as much as 70%. Its ability to replicate the effects of calorie restriction, to boost the immune system and prevent a variety of diseases are all indicators that Resveratrol may play a huge role in increasing life span and quality of life. (18)
 

More On Resveratrol...

We've already mentioned that Resveratrol helps keep cells in our body safe from free radicals. We discussed its effects on the diseases related to aging. We mentioned its anti-aging benefits. Other recent studies claim that Resveratrol can improve the performance of the brain and heart, and increase the life-span of the cells in our bodies. Many nutritionists and health professionals prescribe Resveratrol for people with a poor immune system or who are recovering from an illness. Others prescribe it as an anti-inflammatory.

What doctors are mainly focusing on is increasing the human lifespan by activating the body's natural, genetic defenses against diseases using the Resveratrol which is found in our RevUp31 formula. Imagine being 90 yrs old and living like a 60 yr old! Imagine being 90 and playing tennis, running around with the grandkids, watching them graduate from college, traveling the world.
 

Sources

1) Elliott PJ, Jirousek, M. (2008). "Sirtuins: Novel targets for metabolic disease". Current Opinion in Investigational Drugs

2) Harvard Medical School Staff. Small Molecule Increases Lifespan and Healthspan of Obese Mice. Harvard Medical School Office of Public Affairs.

3) Lu, C., Bambang, I.F., Armstrong, J.S., Whiteman, M. Resveratrol blocks high glucose-induced mitochondrial reactive oxygen species production in bovine aortic endothelial cells: role of phase 2 enzyme induction. Diabetes, Obesity & Metabolism, April 2008.

4) Hingdon, Jane. Resveratrol. Linus Pauling Institute Micronutrient Research for Optimum Health, 2005. Updated 2008 by Drake, Victoria J.

5) Mayo Clinic Staff. Red Wine and Resveratrol: Good for your Heart? Mayo Foundation for Medical Education and Research (MFMER), 2009.

6) National Cancer Institute Staff. Red Wine and Cancer Prevention: Fact Sheet. National Cancer Institute (part of U.S. National Institutes of Health), 2002.

7) http://en.wikipedia.org/wiki/Resveratrol#cite_note-pmid8985016-9: Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997). "Cancer chemopreventive activity of Resveratrol, a natural product derived from grapes".

8) http://en.wikipedia.org/wiki/Resveratrol: Athar M, Back JH, Tang X, et al. (November 2007). "Resveratrol: a review of preclinical studies for human cancer prevention

9) Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C (April 2005). "Resveratrol and breast cancer risk"

10) Garvin S, Ollinger K, Dabrosin C (January 2006). "Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo".

11) Borra, Margie T., Denu, John M., Smith, Brian C. Mechanism of Human SIRT1 Activation by Resveratrol. J. Biological Chemistry, Vol. 280, Issue 17, April 29, 2005.

12) Lagouge M, Argmann C, Gerhart-Hines Z, et al. (2006). "Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha".

13) Barclay, Laurie M.D. Growing Evidence Links Resveratrol to Extended Life Span. Life Extension, March 2007.

14) Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006). "Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate". Current Biology

15) Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE (November 2008). "Dietary supplementation with Resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease".

16) Boocock DJ, Faust GE, Patel KR, et al. (June 2007). "Phase I dose escalation pharmacokinetic study in healthy volunteers of Resveratrol, a potential cancer chemopreventive agent".

17) Alcaín FJ, Villalba JM (April 2009). "Sirtuin activators". Expert Opin Ther Pat

18) Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (September 2004). "Sir2-independent life span extension by calorie restriction in yeast

19) Kaeberlein M, McDonagh T, Heltweg B, et al. (April 2005). "Substrate-specific activation of sirtuins by Resveratrol"

20) Bråkenhielm E, Cao R, Cao Y (August 2001). "Suppression of angiogenesis, tumor growth, and wound healing by Resveratrol, a natural compound in red wine and grapes"

21) Cao Y, Fu ZD, Wang F, Liu HY, Han R (2005). "Anti-angiogenic activity of Resveratrol, a natural compound from medicinal plants"

22) Hung LM, Chen JK, Huang SS, Lee RS, Su MJ (2000). "Cardioprotective effect of Resveratrol, a natural antioxidant derived from grapes".

Additional Sources

* Davidson, Sara. "A Longer, Better Life." New York Times. May 6, 2007. (April 20, 2009)
http://www.nytimes.com/2007/05/06/magazine/06dialogue-t.html?scp=13&sq=anti-aging%20gene&st=cse
* Dreifus, Claudia. "Live Longer with Evolution? Evidence May Lie in Fruit Flies." New York Times. Dec. 6, 2005. (April 20, 2009)
http://www.nytimes.com/2005/12/06/science/06conv.html?scp=6&sq=anti-aging%20gene&st=cse
* Geddes, Linda. "Has universal ageing mechanism been found?" New Scientist. Nov. 26, 2008. (April 20, 2009)
http://www.newscientist.com/article/dn16143-has-universal-ageing-mechanism-been-found.html
* Kolata, Gina. "The Drug Industry's Holy Grail." New York Times. Nov. 9, 2003. (April 20, 2009)
http://www.nytimes.com/2003/11/09/weekinreview/ideas-trends-the-drug-industry-s-holy-grail.html?scp=11&sq=anti-aging%20gene&st=cse
* Mason, Michael. "One for the Ages: A Prescription That May Extend Life." New York Times. Oct. 31, 2006. (April 20, 2009)
http://www.nytimes.com/2006/10/31/health/nutrition/31agin.html?_r=1&scp=4&sq=anti-aging%20gene&st=cse
* Pollack, Andrew. "Forget Botox. Anti-Aging Pills May Be Next." New York Times. Sept. 21, 2003. (April 20, 2009)
http://www.nytimes.com/2003/09/21/business/forget-botox-anti-aging-pills-may-be-next.html?&scp=2&sq=anti-aging%20gene&st=cse
* Sinclair, David. "The Achilles' Heel of Aging." Seed Magazine. April 20, 2009. (April 20, 2009)
http://seedmagazine.com/content/article/the_achilles_heel_of_aging/
* Sinclair, David and Lenny Gaurente. "Unlocking the Secrets of Longevity Genes." Scientific American. Feb. 20, 2006. (April 20, 2009)
http://www.sciam.com/article.cfm?id=unlocking-the-secrets-of-2006-03
* Singer, Emily. "Red wine chemical extends life -- in yeast." New Scientist. Aug. 24, 2003. (April 20, 2009)
http://www.newscientist.com/article/dn4085-red-wine-chemical-extends-life--in-yeast.html
* Wade, Nicholas. "A Pill to Extend Life? Don't Dismiss the Notion Too Quickly." New York Times. Sept. 22, 2000. (April 20, 2009)
http://www.nytimes.com/2000/09/22/us/a-pill-to-extend-life-don-t-dismiss-the-notion-too-quickly.html?sec=health&spon=&&scp=4&sq=SIR2&st=cse
* Wade, Nicholas. "Aging Drugs: Hardest Test is Still Ahead." New York Times. Nov. 7, 2006. (April 20, 2009)
http://www.nytimes.com/2006/11/07/science/07drug.html?scp=7&sq=SIR2&st=cse
* Wade, Nicholas. "From a Yeast Cell, a New Look at the Process of Aging." New York Times. Feb. 20, 2000. (April 20, 2009)
http://www.nytimes.com/2000/02/22/science/from-a-yeast-cell-a-new-look-at-the-process-of-aging.html?scp=1&sq=SIR2&st=cse
* Wade, Nicholas. "Study Spurs Hope of Finding Way to Increase Human Life." New York Times. Aug. 25, 2003. (April 20, 2009)
http://www.nytimes.com/2003/08/25/us/study-spurs-hope-of-finding-way-to-increase-human-life.html?scp=9&sq=SIR2&st=cse
* Wade, Nicholas. "Yes, Red Wine Holds Answer. Check Dosage." New York Times. Nov. 2, 2006. (April 20, 2009)
http://www.nytimes.com/2006/11/02/science/02drug.html?scp=20&sq=SIR2&st=cse


 
 
 
 
 
 
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